Figure 2.

Correlational studies using Spearman’s coefficient. The statistical dependence between the rankings of gender, age, disease severity and mutational hallmark was analyzed in the 63 samples of the 20E (EU1) variant (a). The correlation was also investigated between gender, age and disease severity in the cases without (b) or with (c) additional spike mutations, and in the subset of genomes with relevant mutations (d). The Spearman’s coefficients obtained in each case are indicated in the corresponding box. An asterisk indicates a significant correlation between age and disease severity in (a–c) with p-values of 0.0006, 0.0211 and 0.0001, respectively.