Table 2.
Genomes 20E (EU1) with additional mutations in the spike protein. D614G and A222V are the specific signature substitutions for lineage B.1 and derived sublineage B.1.177, respectively. Additional changes are indicated in italics, and among them are those of concern in bold. The presence of a 3 amino acid deletion in ORF1a is also noted, as it should be considered relevant since it appears in 4 of the 5 VOCs and some VOIs.
| Sample Name | GISAID Accession ID | Mutations in Spike | Presence of ORF1a: S3675-, G3676- and F3677-Deletion |
|---|---|---|---|
| RS23 | EPI_ISL_11623867 | A222V, D614G, Q675H | No |
| RS25 | EPI_ISL_11634150 | T19R, A222V, D614G | No |
| RS26 | EPI_ISL_11634151 | S98F, A222V, D614G | No |
| RS34 | EPI_ISL_11635219 | A222V, D614G, P681H, T716I | No |
| RS38 | EPI_ISL_11646217 | A222V, S254P, A262S, D614G, P809S | No |
| RS40 | EPI_ISL_11685202 | Δ69–70, A222V, E484K, D614G, A701G, P1069S | Yes |
| RS48 | EPI_ISL_11696722 | T95I, A222V, D614G, A1020S | No |
| RS50 | EPI_ISL_11696733 | T20N, A222V, D614G | No |
| RS52 | EPI_ISL_11696749 | A222V, S254P, A262S, D614G, P809S | No |
| RS56 | EPI_ISL_11728097 | T95I, A222V, D614G, A1020S | No |
| RS62 | EPI_ISL_11755017 | A222V, P251H, D614G | No |
| RS63 | EPI_ISL_11755804 | T95I, A222V, D614G, A1020S | No |
| RS67 | EPI_ISL_11760681 | F192L, A222V, D614G | Yes |
| RS69 | EPI_ISL_11765429 | A222V, D614G, N658D | No |
| RS73 | EPI_ISL_11767045 | A222V, E484K, D614G, A701G, P1069S | Yes |
| RS101 | EPI_ISL_11794379 | M153I, A222V, D614G | No |