Table A1.
Previous animal model studies on TBI, sleep dysfunction, and melatonin.
| Citation | Design | Title |
|---|---|---|
| Rehman et al., 2019 [178] | RCT Mice | Neurological Enhancement Effects of Melatonin Against Brain Injury-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration via Ampk/Creb Signaling |
| Naeser et al., 2016 [179] | LED Human | Transcranial, Red/Near-Infrared Light-Emitting Diode Therapy to Improve Cognition in Chronic Traumatic Brain Injury |
| Ge et al., 2020 [180] | Rats | Effect of Melatonin on Regeneration of Cortical Neurons in Rats with Traumatic Brain Injury |
| Ozdemir et al., 2005 [181] | Rats | Protective Effect of Melatonin Against Head Trauma-Induced Hippocampal Damage and Spatial Memory Deficits in Immature Rats |
| Bao et al., 2019 [182] | Rats | Silencing of A20 Aggravates Neuronal Death and Inflammation After Traumatic Brain Injury: A Potential Trigger of Necroptosis |
| Osier et al., 2017 [18] | RCT Rats | Brain Injury Results in Lower Levels of Melatonin Receptors’ Subtypes MT1 and MT2 |
| Wang et al., 2012 [183] | Model | Melatonin Activates the NRF2-Are Pathway When It Protects Against Early Brain Injury in a Subarachnoid Hemorrhage Model |
| Ding et al., 2014 [156] | Model | Melatonin Stimulates Antioxidant Enzymes and Reduces Oxidative Stress in Experimental Traumatic Brain Injury: The NRF2-Are Signaling Pathway as a Potential Mechanism |
| Senol et al., 2014 [184] | Rats | Melatonin Reduces Traumatic Brain Injury-Induced Oxidative Stress in the Cerebral Cortex and Blood of Rats |
| Ding et al., 2015 [185] | Rats | Melatonin Protects the Brain from Apoptosis by Enhancement of Autophagy After Traumatic Brain Injury in Mice |
| Ates et al., 2006 [186] | Rats | Effect of Pinealectomy and Melatonin Replacement on Morphological and Biochemical Recovery After Traumatic Brain Injury |
| Beni et al., 2004 [187] | Rats | Melatonin-Induced Neuroprotection after Closed Head Injury is Associated with Increased Brain Antioxidants and Attenuated Late-Phase Activation of Nf-кB and Ap-1 |
| Campolo et al., 2013 [102] | Rats | Combination Therapy with Melatonin and Dexamethasone in a Mouse Model of Traumatic Brain Injury |
| Dehghan et al., 2013 [188] | Rats | Effect of Melatonin on Intracranial Pressure and Brain Edema Following Traumatic Brain Injury: Role of Oxidative Stresses |
| Ding et al., 2014 [189] | Rats | Melatonin Reduced Microglial Activation and Alleviated Neuroinflammation Induced Neuron Degeneration in Experimental Traumatic Brain Injury: Possible Involvement of Mtor Pathway |
| Ding et al., 2015 [185] | Rats | Melatonin Protects the Brain from Apoptosis by Enhancement of Autophagy After Traumatic Brain Injury in Mice |
| Kabadi et al., 2010 [190] | Rats | Posttreatment With Uridine and Melatonin Following Traumatic Brain Injury Reduces Edema in Various Brain Regions in Rats |
| Kelso et al., 2011 [191] | Rats | Melatonin and Minocycline for Combinatorial Therapy to Improve Functional and Histopathological Deficits Following Traumatic Brain Injury |
| Lin et al., 2016 [192] | Rats | Melatonin Attenuates Traumatic Brain Injury-Induced Inflammation: A Possible Role for Mitophagy |
| Mesenge et al., 1998 [193] | Rats | Protective Effect of Melatonin in a Model of Traumatic Brain Injury in Mice |
| Sarrafzadeh et al., 2000 [194] | Rats | Neuroprotective Effect of Melatonin on Cortical Impact Injury in the Rat |
| Wu et al., 2016 [195] | Rats | Melatonin Attenuates Neuronal Apoptosis Through Up-Regulation of K(+)-Cl(−) Cotransporter KCC2 Expression Following Traumatic Brain Injury in Rats |
| Yamakawa et al., 2017 [196] | Rats | Manipulating Cognitive Reserve: Pre-injury Environmental Conditions Influence the Severity of Concussion Symptomology, Gene Expression, and Response to Melatonin Treatment in Rats |
| Ran et al., 2021 [160] | Rats | Melatonin Protects Against Ischemic Brain Injury by Modulating pi3K/Akt Signaling Pathway via Suppression of Pten |
| Wang et al., 2022 [159] | Rats | Melatonin Protected Against Myocardial Infarction Injury in Rats Through a SIRT6-Dependent Antioxidant Pathway |
| Rui et al., 2021 [19] | Mice | Deletion of Ferritin H in Neurons Counteracts the Protective Effect of Melatonin Against Traumatic Brain Injury-induced Ferroptosis |