Table 1.
Non-viral vectors to deliver genes into injured hearts.
| Delivery method | Target gene | Species | Reference |
|---|---|---|---|
| DNA plasmid | VEGF A-165 | Human, Pig, Sheep | [66–68] |
| PEGylated-NP | Schisandrin B | Rat | [77] |
| PEGylated-NP | Baicalin | Rat | [78] |
| PEGylated-NP | Puerarin | Rat | [79] |
| PLGA-NP | Cyclosporine A | Mouse | [80] |
| PLGA-NP | Irbesartan | Mouse | [81] |
| PLGA-NP | Pitavastatin | Mouse, Rat, Pig | [82–84] |
| PLGA-NP | VEGF | Mouse | [85] |
| PLGA-NP | IGF1 | Mouse | [86] |
| Conjugate chitosan-graft-PEI-eprosartan | VEGF | Rat | [87] |
| PDMA | EGFP | Mouse | [88] |
| Hydrogel | miR-302 | Mouse | [91] |
| Hydrogel | miR-199a-3p | Rat | [92] |
| Hydrogel | miR-21–5p | Pig | [93] |
| UTM | VEGF | Mouse | [94] |
PEGylated-NP, nanoparticles with polyethylene glycol; PLGA-NP, a copolymer (lactic-co-glycolic acid); PEI, polyethylenimine; PDMA, a cationic poly(beta-amino ester); UTM, the ultrasound-targeted microbubble; VEGF, vascular endothelial growth factor; IGF, insulin-like growth factor; EGFP, enhanced green fluorescent protein.