Table 2.
Viral vectors to deliver genes into injured hearts.
| Virus | Target gene | Species | Reference |
|---|---|---|---|
| Adenovirus | VEGF-DΔNΔC | Human | [100] |
| Adenylyl cyclase 6 | Human | [101] | |
| VEGF, Angiopoietin-1 | Pig | [102] | |
| Proline/arginine-rich peptide 39 | Pig | [103] | |
| FGF4 | Pig, Human | [104, 105] | |
| VEGF121 | Human | [106] | |
| Cyclin A2 | Pig | [107] | |
| Cyclin D1, CDK4 | Rat | [108] | |
| CDK1, CDK4, Cyclin B1, Cyclin D1 | Mouse | [21] | |
| AAV | SERCA2a | Human | [115] |
| BNP116 | Human | ClnicalTrials.gov Identifier: NCT04179643 | |
| Glycoprotein 130 | Mouse | [116] | |
| miRNA-LRP6 | Mouse | [117] | |
| Lysophosphatidic acid 3 | Mouse | [118] | |
| miR-199a | Pig | [119] | |
| Lentivirus | miR302–367 | Mouse | [127] |
| CDK1, CDK4, CyclinB1, CyclinD1 | Rat, Pig | [128] | |
| Integrin β1 | Rat | [129] |
AAV, adeno-associated virus; VEGF, vascular endothelial growth factor; FGF, fibroblast growth factor; CDK, cyclin-dependent kinases; SERCA2a, sarcoplasmic/endoplasmic reticulum Ca2+-ATPase; LRP6, low-density lipoprotein receptor-related protein 6.