Table 1.
Details of the GWASs that generated the weights used to calculate PGSs in the MTFS cohort
| Polygenic score | Citation | Assessment of target phenotype | Discovery sample size | h2SNP (%) |
|---|---|---|---|---|
| Drinks per week | Liu et al. (2019) | Average number of drinks a participant reported drinking each week, aggregated across all types of alcohol | 941 280 | 4 |
| Problematic alcohol use | Zhou et al. (2020) | Lifetime diagnosis of alcohol use disorder (ICD) or alcohol dependence (DSM-IV); scores on a measure of problematic drinking (AUDIT-P) | 435 563 | 6–11 |
| Lifetime cannabis use | Pasman et al. (2018) | Self-reported lifetime use of cannabis | 184 765 | 11 |
| Cannabis use disorder | Johnson et al. (2020) | Lifetime diagnosis of cannabis use disorder (DSM-5) or cannabis abuse/dependence (DSM-IV, DSM-III, and ICD-10) | 384 032 | 6–12 |
| Regular smoking | Liu et al. (2019) | Self-reported regular smoking | 1 232 091 | 8 |
| Nicotine dependence | Quach et al. (2020) | Scores on the Fagerstrom Test for Nicotine Dependence (categorized as mild, moderate, or severe) | 58 000 | 9 |
h2SNP, SNP heritability, defined as the fraction of the phenotypic variance explained by the additive effects of all genotyped SNPs; ICD, International Classification of Diseases; DSM, Diagnostic and Statistical Manual of Mental Disorders; AUDIT-P, Alcohol Use Disorders Identification Test, alcohol-related problem items.