Table 3.
Change in Endoscopic Abnormalities and Symptoms With 1FED in Pediatric EoE
| n | Pretreatment | n | Post-treatment | P valuea | |
|---|---|---|---|---|---|
|
| |||||
| Endoscopic findings, n (%) | |||||
| Edema | 41 | 32 (78) | 41 | 22 (54) | .01 |
| Exudate | 41 | 24 (59) | 41 | 10 (24) | .001 |
| Furrows | 41 | 32 (78) | 41 | 22 (54) | .02 |
| Rings | 41 | 8 (20) | 41 | 16 (39) | .04 |
| Stricture | 41 | 0 (0) | 41 | 1 (2) | NDb |
| Inflammatory sum,c median [IQR] | 41 | 2 [2–3] | 41 | 1 [0–2] | <.001 |
| Sum,b median [IQR] | 41 | 3 [2–3] | 41 | 2 [1–3] | .009 |
| Symptoms, n (%) | |||||
| Abdominal pain | 41 | 13 (32) | 38 | 16 (42) | .45 |
| Chest pain | 39 | 10 (26) | 37 | 3 (8) | .039 |
| Dysphagia | 39 | 17 (44) | 38 | 6 (16) | .002 |
| Early satiety | 35 | 15 (43) | 37 | 16 (43) | 1.00 |
| Feeding difficulties | 39 | 10 (26) | 37 | 9 (24) | 1.00 |
| Food impaction | 38 | 10 (26) | 38 | 5 (13) | .15 |
| Gagging/choking | 37 | 7 (19) | 37 | 2 (5) | .22 |
| Heartburn | 37 | 9 (24) | 37 | 8 (22) | 1.00 |
| Nausea | 38 | 10 (26) | 38 | 10 (26) | .77 |
| Odynophagia | 37 | 5 (14) | 37 | 1 (3) | .22 |
| Pockets or spits out food | 36 | 10 (28) | 37 | 3 (8) | .039 |
| Poor appetite | 37 | 10 (27) | 37 | 5 (14) | .13 |
| Reflux or regurgitation | 36 | 11 (31) | 36 | 8 (22) | .69 |
| Slow eating | 38 | 19 (50) | 37 | 11 (30) | .11 |
| Vomiting | 41 | 14 (34) | 38 | 7 (18) | .15 |
| Night wakening | 35 | 7 (19) | 35 | 3 (9) | .51 |
| Symptom sum,d median [IQR] | 41 | 4 [3–6] | 38 | 3 [1–5] | .003 |
NOTE. The Wilcoxon signed-ranked test was used for paired endoscopy and symptom scores. Significant values are bolded, P < .05.
IQR, interquartile range; 1FED, 1-food elimination diet; ND, not determined.
a
Comparison by McNemar test was performed for dichotomous paired data.
b
Sum of edema, exudate, rings, furrows.
c
Sum of edema, exudate, and furrows.
d
Sum of symptoms that are present.