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. Author manuscript; available in PMC: 2023 Apr 24.
Published in final edited form as: Cell Rep. 2023 Mar 2;42(3):112171. doi: 10.1016/j.celrep.2023.112171

Figure 6. IL-10 production by CD169+ macrophages is required for LPS-induced sepsis protection.

Figure 6.

(A) Experimental timeline of LPS challenge of control vs. CD169-IL-10 CKO (IL-10 CKO).

(B) Survival curve between control and IL-10 CKO mice following 75 μg LPS.

(C) (Left to right) IL-10, G-CSF, TNF-α, and IL-6 cytokine levels following 1 h post LPS between control vs. IL-10 CKO.

(D) (Left to right) Splenic Ly6C Hi monocytes, F4/80+ macrophages, CD169+ macrophages, and Ly6G+ neutrophil flow cytometric analysis following 1 h post LPS between control vs. IL-10 CKO mice.

**p < 0.01, ***p < 0.001, ns, not significant. n = 3–5/group and of 2 independent experiments.