Fig. 1.

Select pedigrees from the eoRCC patient cohort and enrichment of predicted pathogenic variants in DNA repair genes in the cohort. A-E. Pedigrees of eoRCC patients with variants in: A— POLD1 and POLH; B— POLE; C— ATM; D— RRM2B and BCL2L1; E— OGG1, NEIL3 and UBR5. F. Summary of variants in genes and pathways, identified in the cohort. In color—number of variants identified for each gene. For detailed information, see Supplementary tables 1 and 2