Table 1.

Prediction of psychological factor scores with PLS regression models based on species, KOs, and protein groups

Mood	Metagenomic (species)			Metagenomic (KOs)			Metaproteomic (protein groups)
	Q2	P	R	Q2	P	R	Q2	P	R
POMS
Total mood disturbance	0.6861	< 0.0001	0.8403	0.6388	< 0.0001	0.8179	0.5112	< 0.0001	0.7595
Tension–anxiety	0.7718	< 0.0001	0.8490	0.4398	< 0.0001	0.7039	0.6664	< 0.0001	0.7363
Anger–hostility	0.7993	< 0.0001	0.9075	0.4206	< 0.0001	0.7121	0.6918	< 0.0001	0.7782
Fatigue–inertia	0.8901	< 0.0001	0.9350	0.6587	< 0.0001	0.8231	0.7415	< 0.0001	0.8415
Depression–dejection	0.7174	< 0.0001	0.8364	0.5124	< 0.0001	0.7145	0.6369	< 0.0001	0.7545
Confusion–bewilderment	0.9012	< 0.0001	0.8989	0.6554	< 0.0001	0.8369	0.7426	< 0.0001	0.8312
Vigour–activity	0.7896	< 0.0001	0.8800	0.7897	< 0.0001	0.8768	0.8127	< 0.0001	0.9014
Self-esteem	0.8358	< 0.0001	0.9071	0.8221	< 0.0001	0.8888	0.8061	< 0.0001	0.9041
SCL-90
SUM-SCL90	0.7262	< 0.0001	0.8682	0.7581	< 0.0001	0.8738	0.7225	< 0.0001	0.7800
Somatization	0.7413	< 0.0001	0.8291	0.7524	< 0.0001	0.8335	0.8439	< 0.0001	0.8822
Obsessive–compulsive	0.9495	< 0.0001	0.9534	0.8352	< 0.0001	0.8968	0.7877	< 0.0001	0.8612
Interpersonal sensitivity	0.8949	< 0.0001	0.9166	0.7748	< 0.0001	0.8400	0.8156	< 0.0001	0.8565
Depression	0.8498	< 0.0001	0.9041	0.5676	< 0.0001	0.7735	0.6934	< 0.0001	0.8355
Anxiety	0.8720	< 0.0001	0.9003	0.5757	< 0.0001	0.7749	0.7752	< 0.0001	0.8694
Hostility	0.6883	< 0.0001	0.7702	0.5713	< 0.0001	0.6475	0.8045	< 0.0001	0.8310
Phobic anxiety	0.9487	< 0.0001	0.6590	0.8935	< 0.0001	0.6529	0.8192	< 0.0001	0.6430
Paranoid ideation	0.6615	< 0.0001	0.8227	0.7745	< 0.0001	0.8438	0.7557	< 0.0001	0.8665
Psychoticism	0.8620	< 0.0001	0.7869	0.8162	< 0.0001	0.7041	0.7374	< 0.0001	0.8101
Additional items	0.8619	< 0.0001	0.8627	0.6186	< 0.0001	0.7002	0.8214	< 0.0001	0.8490

Q², goodness of prediction based on leave-one-out cross-validated PLS regression. R,P, Spearman’s correlation coefficient (R) and P-values