Table 3.
GO, KEGG and BIOCARTA analysis based on DAVID. (Up-DEGs between CIS with CIS + RG108)
| GO | Category | Count | -Log2(P Value) |
|---|---|---|---|
| GOTERM_BP_DIRECT | GO:0015031 ~ protein transport | 16 | 14.06367655 |
| GOTERM_BP_DIRECT | GO:0007264 ~ small GTPase mediated signal transduction 6 | 10.02721346 | |
| GOTERM_BP_DIRECT | GO:0030010 ~ establishment of cell polarity | 4 | 8.62636484 |
| GOTERM_BP_DIRECT | GO:0006895 ~ Golgi to endosome transport | 3 | 7.832803239 |
| GOTERM_BP_DIRECT | GO:0051279 ~ regulation of release of sequestered calcium ion into cytosol | 3 | 7.273426947 |
| GOTERM_BP_DIRECT | GO:0090630 ~ activation of GTPase activity | 5 | 7.128440831 |
| GOTERM_BP_DIRECT | GO:0005794 ~ Golgi apparatus | 29 | 19.91688185 |
| GOTERM_BP_DIRECT | GO:0005737 ~ cytoplasm | 81 | 17.832984 |
| GOTERM_BP_DIRECT | GO:0016020 ~ membrane | 75 | 16.411267 |
| GOTERM_BP_DIRECT | GO:0005829 ~ cytosol | 46 | 8.691662953 |
| GOTERM_CC_DIRECT | GO:0005856 ~ cytoskeleton | 20 | 7.708253097 |
| GOTERM_CC_DIRECT | GO:0071944 ~ cell periphery | 5 | 7.673792745 |
| GOTERM_CC_DIRECT | GO:0035091 ~ phosphatidylinositol binding | 8 | 15.93080634 |
| GOTERM_CC_DIRECT | GO:0031267 ~ small GTPase binding | 9 | 9.466179022 |
| GOTERM_CC_DIRECT | GO:0005085 ~ guanyl-nucleotide exchange factor activity | 89.440037152 | |
| GOTERM_CC_DIRECT | GO:0051015 ~ actin filament binding | 7 | 7.061705217 |
| GOTERM_CC_DIRECT | GO:0000166 ~ nucleotide binding | 23 | 6.964765007 |
| GOTERM_CC_DIRECT | GO:0005096 ~ GTPase activator activity | 7 | 6.72004668 |
| GOTERM_CC_DIRECT | mmu04015:Rap1 signaling pathway | 8 | 9.690665567 |
| GOTERM_CC_DIRECT | mmu04510:Focal adhesion | 7 | 7.858315603 |
| GOTERM_MF_DIRECT | mmu04925:Aldosterone synthesis and secretion | 5 | 7.025230162 |
| GOTERM_MF_DIRECT | mmu04922:Glucagon signaling pathway | 5 | 6.927963163 |
| GOTERM_MF_DIRECT | mmu04360:Axon guidance | 6 | 6.328858772 |
| GOTERM_MF_DIRECT | mmu04720:Long-term potentiation | 4 | 6.097971446 |
| GOTERM_MF_DIRECT | m_agrPathway:Agrin in Postsynaptic Differentiation | 3 | 4.881046309 |
| GOTERM_MF_DIRECT | GO:0015031 ~ protein transport | 16 | 14.06367655 |
| GOTERM_MF_DIRECT | GO:0007264 ~ small GTPase mediated signal transduction | 6 | 10.02721346 |
| GOTERM_MF_DIRECT | GO:0030010 ~ establishment of cell polarity | 4 | 8.62636484 |
| GOTERM_MF_DIRECT | GO:0006895 ~ Golgi to endosome transport | 3 | 7.832803239 |
| GOTERM_MF_DIRECT | GO:0051279 ~ regulation of release of sequestered calcium ion into cytosol | 3 | 7.273426947 |
| KEGG_PATHWAY | GO:0090630 ~ activation of GTPase activity | 5 | 7.128440831 |
| KEGG_PATHWAY | GO:0005794 ~ Golgi apparatus | 29 | 19.91688185 |
| KEGG_PATHWAY | GO:0005737 ~ cytoplasm | 81 | 17.832984 |
| KEGG_PATHWAY | GO:0016020 ~ membrane | 75 | 16.411267 |
| KEGG_PATHWAY | GO:0005829 ~ cytosol | 46 | 8.691662953 |
| KEGG_PATHWAY | GO:0005856 ~ cytoskeleton | 20 | 7.708253097 |
| KEGG_PATHWAY | GO:0071944 ~ cell periphery | 5 | 7.673792745 |
| KEGG_PATHWAY | GO:0035091 ~ phosphatidylinositol binding | 8 | 15.93080634 |
| KEGG_PATHWAY | GO:0031267 ~ small GTPase binding | 9 | 9.466179022 |
| KEGG_PATHWAY | GO:0005085 ~ guanyl-nucleotide exchange factor activity | 8 | 9.440037152 |
| BIOCARTA | GO:0051015 ~ actin filament binding | 7 | 7.061705217 |