Table 4.
GO, KEGG and BIOCARTA analysis based on DAVID. (Down-DEGs between CIS with CIS + RG108)
| GO | Category | Count | -Log2(P Value) |
|---|---|---|---|
| GOTERM_BP_DIRECT | GO:0006334 ~ nucleosome assembly | 22 | 57.66454231 |
| GOTERM_BP_DIRECT | GO:0006335 ~ DNA replication-dependent nucleosome assembly | 10 | 30.27275398 |
| GOTERM_BP_DIRECT | GO:0060968 ~ regulation of gene silencing | 6 | 20.33188326 |
| GOTERM_BP_DIRECT | GO:0051591 ~ response to cAMP | 9 | 19.9964746 |
| GOTERM_BP_DIRECT | GO:0016525 ~ negative regulation of angiogenesis | 11 | 18.86607398 |
| GOTERM_BP_DIRECT | GO:0008285 ~ negative regulation of cell proliferation | 21 | 17.30607279 |
| GOTERM_BP_DIRECT | GO:0000786 ~ nucleosome | 23 | 52.68081271 |
| GOTERM_BP_DIRECT | GO:0005615 ~ extracellular space | 70 | 39.16518262 |
| GOTERM_BP_DIRECT | GO:0005576 ~ extracellular region | 60 | 27.78074552 |
| GOTERM_BP_DIRECT | GO:0000228 ~ nuclear chromosome | 10 | 24.06682693 |
| GOTERM_CC_DIRECT | GO:0031012 ~ extracellular matrix | 14 | 11.84546899 |
| GOTERM_CC_DIRECT | GO:0001533 ~ cornified envelope 7 11.55713079 | ||
| GOTERM_CC_DIRECT | GO:0005125 ~ cytokine activity | 20 | 27.37639108 |
| GOTERM_CC_DIRECT | GO:0008083 ~ growth factor activity | 14 | 20.21950581 |
| GOTERM_CC_DIRECT | GO:0046982 ~ protein heterodimerization activity | 22 | 20.09644873 |
| GOTERM_CC_DIRECT | GO:0030527 ~ structural constituent of chromatin | 5 | 18.90260936 |
| GOTERM_CC_DIRECT | GO:0003677 ~ DNA binding | 51 | 13.59133025 |
| GOTERM_CC_DIRECT | GO:0031492 ~ nucleosomal DNA binding | 5 | 11.73647731 |
| GOTERM_CC_DIRECT | mmu05322:Systemic lupus erythematosus | 19 | 33.78373863 |
| GOTERM_CC_DIRECT | mmu04060:Cytokine-cytokine receptor interaction | 23 | 27.47096385 |
| GOTERM_MF_DIRECT | mmu05034:Alcoholism | 19 | 26.09629208 |
| GOTERM_MF_DIRECT | mmu04613:Neutrophil extracellular trap formation | 18 | 23.29859253 |
| GOTERM_MF_DIRECT | mmu04668:TNF signaling pathway | 12 | 17.9973151 |
| GOTERM_MF_DIRECT | mmu04657:IL-17 signaling pathway | 11 | 17.81081119 |
| GOTERM_MF_DIRECT | m_dspPathway:Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases | 4 | 8.521766816 |
| GOTERM_MF_DIRECT | m_ngfPathway:Nerve growth factor pathway (NGF) | 5 | 7.250046074 |
| GOTERM_MF_DIRECT | m_stemPathway:Regulation of hematopoiesis by cytokines | 4 | 6.579771454 |
| GOTERM_MF_DIRECT | m_erythPathway:Erythrocyte Differentiation Pathway | 4 | 6.292419207 |
| GOTERM_MF_DIRECT | m_arenrf2Pathway:Oxidative Stress Induced Gene Expression Via Nrf2 | 4 | 5.339674577 |
| GOTERM_MF_DIRECT | m_il6Pathway:IL 6 signaling pathway | 4 | 4.448413649 |
| KEGG_PATHWAY | GO:0006334 ~ nucleosome assembly | 22 | 57.66454231 |
| KEGG_PATHWAY | GO:0006335 ~ DNA replication-dependent nucleosome assembly | 10 | 30.27275398 |
| KEGG_PATHWAY | GO:0060968 ~ regulation of gene silencing | 6 | 20.33188326 |
| KEGG_PATHWAY | GO:0051591 ~ response to cAMP | 9 | 19.9964746 |
| KEGG_PATHWAY | GO:0016525 ~ negative regulation of angiogenesis | 11 | 18.86607398 |
| KEGG_PATHWAY | GO:0008285 ~ negative regulation of cell proliferation | 21 | 17.30607279 |
| KEGG_PATHWAY | GO:0000786 ~ nucleosome | 23 | 52.68081271 |
| KEGG_PATHWAY | GO:0005615 ~ extracellular space | 70 | 39.16518262 |
| KEGG_PATHWAY | GO:0005576 ~ extracellular region | 60 | 27.78074552 |
| KEGG_PATHWAY | GO:0000228 ~ nuclear chromosome | 10 | 24.06682693 |
| BIOCARTA | GO:0031012 ~ extracellular matrix | 14 | 11.84546899 |