Figure 11.

Comparison of vaccine-induced responses in the context of pre-existing maternal antibodies

Serum anti-gp140 IgG endpoint titer in kits 4 weeks after receiving a booster immunization of (A) RNA-prM/E, (B) RNA-SOSIP-scfl or (C) Protein-SOSIP vaccine. Kits birthed from does receiving saline or RNA-prM/E are grouped together as negative (−) for maternal antibodies, and those birthed from does receiving RNA-SOSIP-scfl or Protein-SOSIP are grouped together as positive (+) for pre-existing maternal antibodies. Data were log₁₀ transformed and compared by Mann-Whitney test to measure statistical differences, which were not statistically significant (ns, p > 0.05).