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. 2023 Mar 24;31(4):1046–1058. doi: 10.1016/j.ymthe.2023.02.022

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Vaccine-induced serum IgG kinetics in NZW female adult rabbits

Rabbits (n = 5 per group) received (A) saline, (B) RNA-prM/E, (C) RNA-SOSIP-scfl-scfl, or (D) Protein-SOSIP. Animals in both RNA groups (B and C) received 100 μg of repRNA formulated with LION and in the protein group (D) received 50 μg of recombinant BG505-SOSIP.664 trimer adjuvanted with the squalene emulsion adjuvant AddaVax. Sera were assayed by antigen-specific ELISA to measure binding antibodies against (top panels) BG505 SOSIP.664 gp140 or (bottom panels) ZIKV E protein. Plotted lines track the binding antibody response of a single animal corresponding to the unique tag number in the legend. Gray shaded regions mark periods when rabbits were mated (week 1) and when kits were born (week 6–7). Arrows indicate immunization time points.