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DAP rescues CFTR function in mouse organoids
(A) Schematic representation of the forskolin-induced swelling (FIS) assay, in which CFTR function can be assessed in mouse- or patient-derived intestinal organoids. (B) Organoids derived from CFTR-NS mouse intestinal cells were exposed to DMSO, DAP, or G418, and CFTR function was assessed by FIS. All the results are representative of three experiments. The p values were calculated by one-way ANOVA: ∗∗∗p < 0.005.
