Table 1.
Ligand on vasculature | Receptor on T cell | Effect of interaction |
Naïve T cells | ||
PNAd | CD62L | Rolling/Tethering |
CCL19 | CCR7 | Integrin activation |
CCL21 | CCR7 | Integrin activation |
ICAM-1 | LFA1 | Firm adhesion/arrest |
Effector T cells | ||
PSGL-1 | P-selectin | Rolling/Tethering |
ESL | E-selectin | Rolling/Tethering |
HA | CD44 | Rolling/Tethering |
CXCL9-11 | CXCR3 | Integrin activation |
VCAM-1 | α4β1 | Firm adhesion/arrest |
ICAM-1 | LFA1 | Firm adhesion/arrest |
MAdCAM1 | α4β7 | Firm adhesion/arrest |
ESL, E-selectin ligand; HA, hyaluronic acid; ICAM-1, intracellular adhesion molecule 1; PNAd, peripheral node addressin; VCAM-1, vascular cell adhesion molecule 1.