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. 2023 Apr 17;11(4):e006401. doi: 10.1136/jitc-2022-006401

Table 1.

Homing receptors and ligands on vasculature

Ligand on vasculature Receptor on T cell Effect of interaction
Naïve T cells
PNAd CD62L Rolling/Tethering
CCL19 CCR7 Integrin activation
CCL21 CCR7 Integrin activation
ICAM-1 LFA1 Firm adhesion/arrest
Effector T cells
PSGL-1 P-selectin Rolling/Tethering
ESL E-selectin Rolling/Tethering
HA CD44 Rolling/Tethering
CXCL9-11 CXCR3 Integrin activation
VCAM-1 α4β1 Firm adhesion/arrest
ICAM-1 LFA1 Firm adhesion/arrest
MAdCAM1 α4β7 Firm adhesion/arrest

ESL, E-selectin ligand; HA, hyaluronic acid; ICAM-1, intracellular adhesion molecule 1; PNAd, peripheral node addressin; VCAM-1, vascular cell adhesion molecule 1.