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. 2023 Apr 17;11(4):e006334. doi: 10.1136/jitc-2022-006334

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Screening of new HCC-dominant neoantigens by specific tetramers. (A) Tetramer staining of PBMCs from patients after stimulation with predicted neoantigen peptides. The irrelevant peptides are isotype controls. The amino acids in the red font are mutation sites. (B) The frequency of the specific T cells after stimulation with predicted neoantigen peptides. (C) The frequency of the specific T cells in PBMCs of patient 04 after stimulation with potential dominant neoantigens and paired WT peptides. (D) The frequency of CD39⁺ CD8⁺ T cells after stimulation with predicted neoantigen peptides. HCC, hepatocellular carcinoma; PBMCs, peripheral blood mononuclear cells; WT, wild type.