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Under Normoxia, Hif protein is eliminated by proteasomal mechanism with the help of PHD and pVHL enzymes. However, depletion of oxygen leads to downregulation of PHD and pVHL, results in translocation of Hif to nucleus and forms complex with Hif1β. This complex promotes the transcription of Hif protein. pVHL- Von Hippel-Lindau protein; PHD- Prolyl-4-hydroxylases
