Table-1:

Effect of differential expression of HIF isoforms

Isoforms	Alterations	Cell line/Model/Organism	Mode of mechanism	Ref
Hif1α	Overexpression	peri-infarct of sheep (n=6) undergoing coronary occlusion	Reduced infarct size and improved LV systolic performance increased neovascularization	Chen et al., 2022
		Hif1α null mouse model	Increased HIF2Α Increased mitochondrial number Impaired embryonic glycolysis Activation of amino acid catabolism	Eubank et al., 2011
	Knockdown	H9c2 cells exposed to high glucose	Downregulated angiopoietin-like protein 2, alleviating the hypoxia injury by promoting nrf2 and HO-1 expression	Ghosh et al., 2021
Hif2α	Overexpression	46C ESC cell line	Promotes cardiomyogenesis by wnt/β-catenin pathway	Hickey et al., 2010
	Knockdown	VHLR200W (Chuvash Polycythemia)mouse model	Normalized erythropoietin and endothelin level suppressed both the polycythemia and pulmonary hypertension partial protection against vascular remodeling, haemorrhage, and edema	Hnatiuk et al., 2016 Menendez-Montes et al., 2021
		HIF-1αflox/flox/LysMcre knockout mice	Inhibited soluble form of the VEGF receptor-1 (sVEGFR-1) production in a hypoxic condition Production of VEGF was unaffected	Sun et al., 2015
Hif3α	Overexpression	-		-
	Knockdown	Hep3B hepatoma cells	Downregulation of EPO gene	Tolonen et al., 2020
Hif3α2	Overexpression	Hep3B hepatoma cells SK-N-AS cells	Promotes expression of erythropoietin gene (EPO), BMP6, PTX3	Tolonen et al., 2020
	Knockdown	-	-	-