Table 2.
The robust gene-by-sex tests (fbatge in fbati package) for atopy, asthma, total IgE, eosinophil count, and skin test reactivity to specific allergens with respect to SNP rs1255383.
| Affection status | GACRS probands (N=889) | CAMP probands (N=284) | Merged probands (N=1,173) | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Informative families* | P interaction | Informative families* | P interaction | Informative families* | Correlation with atopy (φ) | P interaction | ||
| Atopy | 85 | 7.18 × 10−6 | 36 | 5.43 × 10−4 | 121 | - | 9.08 × 10−10 | |
| Asthma | 101 | 4.56 × 10−4 | 42 | 1.05 × 10−3 | 143 | - | 5.86 × 10−7 | |
| Atopy markers | Elevated eosinophil count (≥ 500 cells/ mm3) | 45 | 4.31 × 10−5 | 15 | 4.25 × 10−2 | 60 | 0.291 | 6.20 × 10−7 |
| Elevated total IgE (≥ 100 IU/mL) | 72 | 5.46 × 10−6 | 27 | 2.47 × 10−2 | 99 | 0.469 | 1.37 × 10−7 | |
| Allergens | D. pteronyssinus | 77 | 3.91 × 10−5 | 21 | 7.98 × 10−4 | 98 | 0.626 | 1.37 × 10−8 |
| D. farinae | 72 | 1.10 × 10−5 | 23 | 1.68 × 10−3 | 95 | 0.588 | 9.10 × 10−9 | |
| P. americana | 51 | 1.06 × 10−4 | 6 | 8.29 × 10−2 | 57 | 0.340 | 1.03 × 10−6 | |
| B. germanica | 53 | 3.42 × 10−4 | 10 | 3.72 × 10−2 | 63 | 0.365 | 6.39 × 10−6 | |
| cat hair | 21 | 1.92 × 10−3 | 23 | 5.13 × 10−3 | 44 | 0.228 | 1.07 × 10−5 | |
| dog hair | 9 | 1.59 × 10−1 | 11 | 2.26 × 10−3 | 20 | 0.142 | 0.000379 | |
| A. tenuis | 6 | 3.95 × 10−1 | 12 | 1.04 × 10−2 | 18 | 0.157 | 0.004875 | |
| mixed grass pollen | 6 | 4.81 × 10−2 | 12 | 5.61 × 10−2 | 18 | 0.179 | 0.009275 | |
| mixed tree pollen | 14 | 2.31 × 10−2 | 0 | 1 | 14 | 0.146 | 0.018289 | |
*
Informative families as provided by fbatge.