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. Author manuscript; available in PMC: 2023 Apr 24.
Published in final edited form as: Xenotransplantation. 2018 Aug 20;25(6):e12454. doi: 10.1111/xen.12454

FIGURE 1.

FIGURE 1

Binding of infant human (n = 42) serum antibodies to wild-type (WT, genetically unmodified) and GT-KO pig peripheral blood mononuclear cells (PBMC) (MFI index = mean fluorescence intensity of the serum sample divided by the MFI of the isotype control sample). A, Distribution of IgM reactivity against WT and GT-KO PBMC. Correlation of MFI index with age of each group is indicated by a line (vs WT, P = 0.073, r = 0.316; vs GT-KO, P = 0.129, r = 0.238). When sera from infants were tested, only 2 of 50 serum samples showed (very low) binding of IgM to TKO pig red blood cells (not shown, Hara, et al manuscript in preparation). B, Distribution of IgG reactivity against WT and GT-KO PBMC. Correlation of MFI index with age of each group is indicated by a line (vs WT, P = 0.381, r = −0.158; vs GT-KO, P = 0.021, r = 0.356). When sera from infants were tested, no IgG binding to TKO cells was detected in any of the 50 samples (not shown, Hara, et al manuscript in preparation). (Reproduced with permission from Rood et al Transplant Int 2007;20:1050-1058.)