Table 1. Summary of 2′-deoxynucleotide inhibitions and enhancements of G11 self-cleavage.
| Nucleotide | Sample size | Cleaved:uncleaved | SD |
|---|---|---|---|
| U628 | 10 | 0.52 | 0.26 |
| C634 | 10 | 0.83 | 0.14 |
| C635 | 10 | 0.78 | 0.12 |
| C636 | 10 | 0.81 | 0.21 |
| C637 | 10 | 0.80 | 0.16 |
| A639 | 8 | 1.83 | 0.72 |
| U644 | 10 | 1.57 | 0.24 |
| G654 | 8 | 0.45 | 0.09 |
| G655 | 8 | 0.43 | 0.08 |
| U659 | 10 | 0.66 | 0.34 |
| U686 | 10 | 0.60 | 0.33 |
| U696 | 10 | 0.51 | 0.21 |
| A698 | 10 | 0.50 | 0.08 |
| A701 | 10 | 0.18 | 0.09 |
| U710 | 10 | 0.40 | 0.14 |
| A712 | 10 | 0.23 | 0.12 |
| U713 | 10 | 0.65 | 0.18 |
| U753 | 9 | 0.67 | 0.25 |
| G754 | 8 | 0.63 | 0.12 |
| A756 | 10 | 0.37 | 0.08 |
| A767 | 10 | 1.60 | 0.63 |
| C770 | 10 | 0.34 | 0.21 |
| C771 | 10 | 0.22 | 0.14 |
| G772 | 8 | 0.43 | 0.23 |
All effects of 2′-deoxynucleotide substitution that were found to be statistically significant at the 95% confidence level (red symbols in Fig. 1) are listed. The ratio of cleaved:uncleaved was determined as described in the Materials and Methods. The average of 8–10 experiments (sample size) is given with one standard deviation (SD).