Table 2. Univariable linear mixed effects model regression analysis between implicit times and explanatory variables.
| regression coefficient (β) | 95% CI [0.025, 0.975] | p- value | p- value corrected using the Holm-Bonferroni method | |
|---|---|---|---|---|
| BCVA (logMAR units) | 1.2 | 0.59, 1.8 | <0.001* | 0.0044* |
| IOP (mmHg) | 5.5×10−2 | 8.2×10−3, 0.10 | 0.022* | n.s. |
| Axial length (mm) | 0.25 | 0.15, 0.35 | <0.001* | <0.001* |
| Pupil Area (mm2) | 1.5×10−2 | -3.4×10−2, 6.4×10−2 | 0.55 | n.s. |
| Sex-Male | 0.19 | -4.2×10−2, 0.43 | 0.11 | n.s. |
| Sex-Female | -0.19 | -0.43, 4.2×10−2 | 0.11 | n.s. |
| Age (years) | 3.9×10−2 | 2.7×10−2, 5.1×10−2 | <0.001* | <0.001* |
| Height (cm) | 7.6×10−3 | -6.3×10−3, 2.1×10−2 | 0.28 | n.s. |
| BMI (kg/m2) | 4.7×10−2 | 1.2×10−2, 8.1×10−2 | 0.008* | n.s. |
| Systolic BP (mmHg) | 4.3×10−3 | -1.4×10−3, 9.9×10−3 | 0.14 | n.s. |
| Diastolic BP (mmHg) | 5.6×10−4 | -7.9×10−3, 9.0×10−3 | 0.90 | n.s. |
| average BP (mmHg) | 2.9×10−3 | -4.8×10−3, 1.1×10−2 | 0.46 | n.s. |
| Brinkman index (cigarettes・years/day) | -2.2×10−5 | -3.1×10−4, 2.7×10−4 | 0.88 | n.s. |
| IMT (mm) | 0.24 | 2.9×10−2,0.45 | 0.026* | n.s. |
| WBC (103/μL) | 5.2×10−2 | -2.7×10−2, 0.13 | 0.19 | n.s. |
| RBC (104/μL) | 5.9×10−4 | -2.3×10−3, 3.5×10−3 | 0.70 | n.s. |
| Hb (g/dL) | 2.8×10−3 | -9.1×10−2, 9.7×10−2 | 0.95 | n.s. |
| Ht (%) | -4.6×10−4 | -3.2×10−2, 3.1×10−2 | 0.98 | n.s. |
| MCV (fL) | 1.0×10−2 | -3.4×10−2, 1.4×10−2 | 0.39 | n.s. |
| Plt (104/μL) | -3.2×10−3 | -2.7×10−2, 2.1×10−2 | 0.79 | n.s. |
| HbA1c (%) | 0.28 | 5.4×10−2, 0.51 | 0.016* | n.s. |
| BS (mg/dL) | 1.4×10−2 | 5.3×10−4, 2.2×10−2 | 0.0015* | 0.0495* |
| Protein (g/dL) | -0.14 | -0.44, 0.16 | 0.36 | n.s. |
| Alb (g/dL) | -0.43 | -0.90, 5.4×10−2 | 0.083 | n.s. |
| ALP (U/L) | 8.7×10−4 | -9.9×10−4, 2.7×10−3 | 0.36 | n.s. |
| GOT (U/L) | 9.5×10−3 | -4.7×10−3, 2.4×10−2 | 0.19 | n.s. |
| GPT (U/L) | 4.7×10−3 | -2.9×10−3, 1.2×10−2 | 0.22 | n.s. |
| γGTP (U/L) | 2.9×10−3 | 5.5×10−4, 5.2×10−3 | 0.016* | n.s. |
| Total cholesterol (mg/dL) | -1.9×10−3 | -5.2×10−3, 1.5×10−3 | 0.28 | n.s. |
| TG (mg/dL) | 7.1×10−4 | -1.2×10−3, 2.6×10−3 | 0.47 | n.s. |
| HDL (mg/dL) | -7.4×10−4 | -1.5×10−2, 6.6×10−4 | 0.073 | n.s. |
| LDL (mg/dL) | -2.9×10−3 | -6.7×10−3, 8.3×10−4 | 0.13 | n.s. |
| BUN (mg/dL) | 5.9×10−2 | 2.9×10−2, 9.0×10−2 | <0.001* | 0.0052* |
| Cre (mg/dL) | 0.82 | 0.12, 1.5 | 0.023* | n.s. |
| Uric acid (mg/dL) | 0.13 | 4.6×10−2, 0.22 | 0.0030* | n.s. |
| Ca (mg/dL) | -9.2×10−2 | -0.51, 0.33 | 0.67 | n.s. |
| CRP (mg/dL) | 0.38 | -0.16, 0.92 | 0.16 | n.s. |
CI, confidence interval; BCVA, best-corrected visual acuity; IOP, Intraocular pressure; BMI, Body mass index; BP, Blood pressure; IMT, Intima Media Thickness; WBC, white blood cell; RBC, red blood cell; Hb, hemoglobin; Ht, hematocrit; MCV, mean corpuscular volume; Plt, Platelet; HbA1c, Hemoglobin A1c; BS, Blood sugar; Alb, albumin; ALP, alkaline phosphatase; GOT, glutamic oxaloacetic transaminase; GPT, glutamic pyruvic transaminase; γGTP, γ- glutamyl transpeptidase; TG, triglyceride; HDL, high density lipoprotein cholesterol; LDL, low density lipoprotein cholesterol; BUN, Blood urea nitrogen; Cre, Creatinine; Ca, calcium; CRP, C-reactive protein; n.s., not significant.
* means p- value <0.05
Adjusted P values for factors that were not significant in univariable models are not shown because they are also not significant after Holm-Bonferroni adjustment.