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. 2023 Mar 11;299(4):104601. doi: 10.1016/j.jbc.2023.104601

Figure 4.

Figure 4

Structural basis for the recognition of H3K14acyl by DPF and of H3 by PZP.A, the crystal structure of the MORF DPF domain in complex with H3K14bu (PDB ID: 5U2J). DPF is shown in ribbon diagram with PHD1 and PHD2 colored blue and gray, respectively, and H3K14bu peptide is colored orange. The histone peptide residues are labeled. Dashed lines indicate hydrogen bonds. B, overlay of the structures of the H3(1–6)-bound AF10 PZP (PDB ID 7MJU) and H3(20–28)-bound AF10 PZP (PDB ID 5DAH). Electrostatic surface potential of AF10 PZP (shown only for PDB ID 7MJU), with blue and red colors representing positive and negative charges, respectively. The histone regions H3(1–6) and H3(20–28) are green and blue, respectively. DPF, double PHD finger; PHD, plant homeodomain.