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The influence of TDG’s NTD and CTD on RNA binding.A, TDG domains discussed in this work. The basic patch within the NTD (residues 82–110) is highlighted. B, TDG truncations tested (left) and their affinity for homopolymeric RNAs (right). Shown are Kd values (nM) with 95% CIs in parentheses (n = 3). Representative EMSA data and saturation binding plots are shown in Figs. S7–S9. EMSA, electrophoretic mobility shift assay; TDG, Thymine DNA glycosylase; NTD, N-terminal domain.
