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. 2023 Mar 6;299(4):104590. doi: 10.1016/j.jbc.2023.104590

Table 1.

Equilibrium dissociation constants and Hill coefficients (h) for TDG binding to various RNA and DNA strands.

Sequence Kd (nM) 95% CI Hill (h) 95% CI
G30 434 396–473 1.6 1.4–1.9
C30 >5000 --- --- ---
A30 >5000 --- --- ---
U30 >5000 --- --- ---
(GA)20 140 118–165 2.9 2.2–4.0
(GA)15 410 375–447 1.7 1.5–2.0
(GA)10 2420 1890–3278 1.1 0.9–1.4
(GA)5 >8097 6704–10,506 1.2 1.0–1.5
d(GA)20 1448 1289–1656 0.9 0.9–1.0
(GU)20 319 301–338 2.2 1.9–2.5
(G3A4)4 366 338–394 1.3 1.2–1.4
(GGAA)10 423 376–472 2.2 1.7–2.9
d(GGAA)10 2287 2106–2494 2.3 2.0–2.7
L-(GGAA)10 532 505–559 3.4 2.9–4.0
GCHP 2896 3242–4842 2.2 1.7–2.9
MUTHP 139 127–153 2.9 2.0–3.8
HOTAIR 39 36–41 2.7 2.3–3.2
TFF1e 104 100–108 3.7 3.2–4.4

95% CI, 95% confidence interval; TDG, Thymine DNA glycosylase; TFF1e, TFF1 enhancer RNA transcript; HOTAIR, HOX antisense intergenic RNA.