Table 2.

Summary of ongoing trials in syndrome of ischemia with non-obstructive coronary arteries (INOCA)

Trial	Objective
The WARRIOR trial (NCT03417388) [24, 26•]	Evaluate the benefit of intensive medical therapy with statin, angiotensin-converting enzyme inhibitors/angiotensin receptor blocker therapy, aspirin and lifestyle counseling and their impact on major adverse cardiac events in symptomatic women with INOCA
The PRIZE trial (NCT04097314) [27]	The Precision Medicine With Zibotentan in Microvascular Angina (PRIZE) trial’s goal is to assess the benefit of zibotentan, an oral endothelin A receptor antagonist, in patients with microvascular dysfunction. The primary outcome of the PRIZE trial is to assess the treadmill exercise duration using the Bruce protocol
The CorCTCA trial (NCT03477890) [28]	The trial’s aim is to clarify the prevalence and outcomes of INOCA when coronary computed tomography angiography is used as the initial diagnostic modality. Primary outcome is reclassification of the initial computed tomography’s diagnosis based on the interventional diagnostic procedure