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. 2023 Apr 24;12:e83545. doi: 10.7554/eLife.83545

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© 2023, Villalobos-Cantor et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 5. — (A) No significant effect of pan-neuronal or pan-glial PGA expression on negative geotaxis behavior at 3 and 6 weeks of age (two-way ANOVA for the effect of age (p<0.0001) and genotype, (n.s.), n=3–6 groups of 25 flies/genotype/age). (B) Significant effect of ubiquitous PGA expression on negative geotaxis behavior at 3 weeks of age (two-way ANOVA for the effect of age (p<0.0001) and genotype (p<0.0001), Bonferroni post-test, ****p<0.0001, n=5–6 groups of 25 flies/genotype/age). (C) Survival is slightly extended upon pan-neuronal or pan-glial PGA expression. (D) Significant effect of ubiquitous PGA expression on survival. For C and D, see Tables 1 and 2 for experimental n, lifespan metrics, and log-rank (Mantel-Cox) comparison results. Data are mean ± SEM. See also Figure 5—figure supplement 1.

Figure 5—figure supplement 1. — (A) No significant effect of pan-neuronal or pan-glial PGA expression on negative geotaxis behavior at 3 and 6 weeks of age (two-way ANOVA for the effect of age (p<0.0001) and genotype, (n.s.), n=3–6 groups of 25 flies/genotype/age). (B) Significant effect of ubiquitous PGA expression on negative geotaxis behavior at 3 weeks of age (two-way ANOVA for the effect of age (p<0.0001) and genotype (p<0.0001), Bonferroni post-test, ****p<0.0001, n=5–6 groups of 25 flies/genotype/age). (C) Survival is slightly extended upon pan-neuronal or pan-glial PGA expression. (D) Significant effect of ubiquitous PGA expression on survival. For C and D, see Tables 1 and 2 for experimental n, lifespan metrics, and log-rank (Mantel-Cox) comparison results. Data are mean ± SEM. See also Figure 5—figure supplement 1.