TABLE 2.
Differences between TCMR1 and TCMR2 in 25 scores for histology lesions and molecular scores
| No rejection (N = 1040) | TCMR1 (N = 75) | TCMR2(N = 100) | P value for TCMR1 vs TCMR2 | ||
|---|---|---|---|---|---|
| 9 histology lesion scores | |||||
| TCMR-related | t (tubulitis) | 0.30 | 2.19 | 2.00 | 0.09 |
| i (interstitial infiltrate) | 0.32 | 2.16 | 1.92 | 0.16 | |
| All rejection-related | v (vasculitis) | 0.01 | 0.37 | 0.07 | 0.0002 |
| AMR-related | g (glomerulitis) | 0.27 | 0.50 | 0.18 | 0.01 |
| ptc (capillaritis) | 0.25 | 0.32 | 0.60 | 0.01 | |
| Atrophy-fibrosis-related | ci (scarring) | 1.12 | 1.19 | 1.77 | 0.0003 |
| ct (atrophy) | 1.03 | 1.09 | 1.69 | 0.0001 | |
| cv (intimal thickening) | 0.90 | 0.55 | 1.04 | 0.0011 | |
| ah (arteriolar hyalinosis) | 1.00 | 0.21 | 0.73 | <0.0001 | |
| 16 transcript set and molecular classifier scores | |||||
| TCMR-related classifiers | TCMR (TCMRProb) | 0.03 | 0.60 | 0.24 | <0.0001 |
| i-score (i>1Prob) classifier | 0.06 | 0.84 | 0.65 | <0.0001 | |
| t-score (t>1Prob) classifier | 0.06 | 0.83 | 0.62 | <0.0001 | |
| All-rejection-related | RejProb classifier | 0.12 | 0.85 | 0.54 | <0.0001 |
| AMR-related | DSA-selective transcripts (DSAST) | 0.07 | 0.33 | 0.17 | <0.0001 |
| NK cell burden (NKB) | 0.36 | 1.01 | 0.80 | 0.001 | |
| AMR-related classifier (AMRProb) | 0.08 | 0.30 | 0.13 | <0.0001 | |
| Macrophage-related | Alternatively activated macrophage (AMAT1) | 0.40 | 1.53 | 1.23 | <0.0001 |
| Constitutive macrophage (QCMAT) | 0.31 | 1.46 | 1.11 | <0.0001 | |
| Recent injury-related | Fibrillar collagen (FICOL) | 1.11 | 1.61 | 1.58 | 0.72 |
| Injury-repair induced, day 3 (IRITD3) | 0.04 | 0.22 | 0.17 | 0.01 | |
| Injury-repair induced, day 5 (IRITD5) | 0.33 | 0.64 | 0.59 | 0.09 | |
| Injury/repair associated (IRRAT30) | 0.26 | 1.13 | 0.99 | 0.04 | |
| GFRprob | 0.32 | 0.60 | 0.52 | 0.05 | |
| Atrophy-fibrosis related | Fibrosis (ci>1Prob) classifier | 0.31 | 0.40 | 0.53 | 0.001 |
| Atrophy (ct>1 Prob) classifier | 0.26 | 0.30 | 0.46 | <0.0001 | |
Wilcoxon t test was performed between TCMR1 and TCMR2 biopsies for each molecular classifier.
Gray shading indicates significant difference P < 0.01 between TCMR1 and TCMR2.
Bolding indicates the higher value (between TCMR1 or TCMR2) when P < 0.05.
AMR, antibody-mediated rejection; AMRProb, AMR-probability classifier; ci > 1Prob, ci>1-probability classifier; ct > 1Prob, ct > 1-probability classifier; DSA, donor-specific antibody; GFR, glomerular filtration rate; i > 1Prob, i > 1-probability classifier; NK, natural killer; t > 1Prob, t > 1-probability classifier; TCMR, T cell–mediated rejection; TCMRProb, TCMR-probability classifier.