TABLE 5.

Top 20 genes by Spearman correlation decreased (negatively correlated) with time posttransplant within molecular TCMR biopsies (archetypes TCMR1/2; N = 175)

Gene symbol	Gene name	Transcript set	Spearman correlation with time posttransplanta
CXCL9	Chemokine (C-X-C motif) ligand 9	IFNG-inducible	–0.50
GBP1	Guanylate binding protein 1, interferon-inducible	IFNG-inducible	–0.45
CXCL10	Chemokine (C-X-C motif) ligand 10	IFNG-inducible	–0.44
LAG3	Lymphocyte-activation gene 3	T cell–activation gene; TCMR-RAT	–0.44
ANKRD22	Ankyrin repeat domain 22	IFNG-inducible	–0.44
APOL4	Apolipoprotein L, 4	IFNG-inducible	–0.43
CXCL11	Chemokine (C-X-C motif) ligand 11	IFNG-inducible	–0.42
NUSAP1	Nucleolar and spindle associated protein 1	Macrophage; injury-induced (IRITD5)	–0.42
IDO1	Indoleamine 2,3-dioxygenase 1	IFNG-inducible	–0.41
GBP4	Guanylate binding protein 4	IFNG-inducible	–0.41
BATF2	Basic leucine zipper transcription factor, ATF-like 2	IFNG-inducible	–0.41
RGL1	Ral guanine nucleotide dissociation stimulator-like 1	Macrophage gene	–0.40
SMCO4	Single-pass membrane protein with coiled-coil domains 4	IFNG-inducible (macrophages)	–0.40
TAP1	Transporter 1, ATP-binding cassette, subfamily B (MDR)	IFNG-inducible	–0.40
FBXO6	F-box protein 6	IFNG-inducible	–0.40
FAM72A	Family with sequence similarity 72, member A	T cell–activation gene; TCMR-RAT	–0.39
MOB1A	MOB kinase activator 1A	Injury-induced (cIRIT)	–0.39
GABBR1	Gamma-aminobutyric acid B receptor, 1	All rejection	–0.39
IL31RA	Interleukin 31 receptor A	IFNG-inducible	–0.39
RRM2	Ribonucleotide reductase M2	Injury-induced, IRIT5	–0.39

Pseudogenes have been deleted.

PBTs are listed on our home page https://www.ualberta.ca/medicine/institutes-centres-groups/atagc/research/gene-lists.

^aAll P values <0.001.

PBT, pathogenesis-based transcript; TCMR, T cell–mediated rejection.