TABLE 7.
Correlation between histology lesion scores, molecular transcript set scores, and molecular classifier scores with time of biopsy posttransplant in molecular TCMR biopsies >1 y (N = 86)a
| Spearman correlation with time posttransplant | P | ||
|---|---|---|---|
| 9 histology lesion scores | |||
| TCMR related | t (tubulitis) | –0.17 | 0.17 |
| i (interstitial infiltrate) | –0.14 | 0.27 | |
| AMR related | g (glomerulitis) | –0.13 | 0.29 |
| ptc (capillaritis) | –0.15 | 0.25 | |
| All rejection related | v (vasculitis) | –0.21 | 0.10 |
| Atrophy-fibrosis related | ci (scarring) | 0.30 | 0.02 |
| ct (atrophy) | 0.34 | 0.01 | |
| cv (intimal thickening) | 0.32 | 0.01 | |
| ah (hyalinosis) | 0.65 | <0.001 | |
| 16 transcript set scores and classifier scores | |||
| TCMR related classifiers | TCMR (TCMRProb) | –0.27 | 0.01 |
| i-score (i > 1 Prob) classifier | –0.32 | 0.003 | |
| t-score (t > 1 Prob) classifier | –0.37 | 0.0006 | |
| All rejection related | RejectionProb classifier | –0.29 | 0.01 |
| AMR related | DSA-selective transcripts (DSAST) | –0.07 | 0.53 |
| NK cell burden (NKB) | 0.06 | 0.61 | |
| AMR (AMRProb) classifier | –0.17 | 0.11 | |
| Macrophage relatedb | Alternatively activated macrophage (AMAT1) | –0.08 | 0.45 |
| Constitutive macrophage (QCMAT) | –0.15 | 0.17 | |
| Recent injury relatedc | Fibrillar collagen (FICOL) | 0.07 | 0.55 |
| Injury-repair induced, day 3 (IRITD3) | 0.09 | 0.41 | |
| Injury-repair induced, day 5 (IRITD5) | 0.12 | 0.28 | |
| Injury/repair associated (human kidney) (IRRAT30) | 0.14 | 0.19 | |
| Low GFRprob | 0.13 | 0.23 | |
| Atrophy-fibrosis related | Fibrosis (ci > 1 Prob) | 0.34 | 0.002 |
| Atrophy (ct > 1 Prob) | 0.33 | 0.002 | |
PBTs are listed on our home page https://www.ualberta.ca/medicine/institutes-centres-groups/atagc/research/gene-lists.
Shading and bold indicate significant association of the score with time P < 0.05.
All macrophage-related classifier scores were significantly different between TCMR biopsies (N = 175) and NR biopsies (N = 1040) (P < 10–16).
All injury-associated classifier scores were significantly different between TCMR biopsies (N = 175) and NR biopsies (N = 1040) (P < 10–11).
AMR, antibody-mediated rejection; ci > 1Prob, ci > 1-probability classifier; ct > 1Prob, ct > 1-probability classifier; DSA, donor-specific antibody; GFR, glomerular filtration rate; NK, natural killer; PBT, pathogenesis-based transcript; TCMR, T cell–mediated rejection.