TABLE 8.

Expression of checkpoint transcripts in TCMR archetypes (N = 175) in relationship with time posttransplant and to class comparison between TCMR1 and TCMR2

Checkpoints and ligands	Correlation with time posttransplant			Comparing expression in TCMR1 vs TCMR2
	Rank by P	Spearman correlation coefficient	P	Rank by P	TCMR1	TCMR2	No rejection	P	Adjusted P
TIGITa	11 643	–0.13	NS	66	165	94	43	9.41E–16	7.05E–13
BTLA	3193	–0.20	0.008	5446	91	70	19	0.004	0.04
CTLA4	2351	–0.22	0.004	275	58	39	22	3.11E–11	5.59E–09
PDCD1	12 630	–0.12	NS	433	101	82	75	1.05E–09	1.20E–07
CD160b	11 579	–0.13	NS	3607	72	53	25	0.001	0.01
LAG3	32	–0.44	1.0E–09	33	232	132	66	7.48E–18	1.12E–14
CD244/2B4	32 205	–0.05	NS	768	54	43	29	6.80E–08	4.38E–06
HAVCR2/TIM3	35 399	–0.04	NS	336	42	29	20	1.37E–10	2.02E–08
TNFSF9/CD137	7967	–0.15	NS	7	72	35	17	8.75E–21	6.03E–17

^aBold and shaded are checkpoints that do not decrease in expression significantly with time but are higher in TCMR1 than TCMR2.

^bCD160 is included because it is a marker for exhausted T cells.

NS, not significant; TCMR, T cell–mediated rejection.