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. Author manuscript; available in PMC: 2023 Apr 24.
Published in final edited form as: Nat Chem Biol. 2022 Feb 24;18(4):412–421. doi: 10.1038/s41589-022-00971-2

Extended Data Figure 5. Effect of DUBTACs on mutant CFTR levels.

Extended Data Figure 5.

CFBE41o-4.7 cells expressing ΔF508-CFTR were treated with vehicle DMSO or NJH-2-057 and CFTR and loading control GAPDH levels were assessed by Western blotting. For dose-response studies, NJH-2-057 was treated for 24 h. For time-course studies, NJH-2-057 was treated at 10 μM. Dose-response and time-course data gels are representative of n=3 biologically independent samples/group and are quantified in the bar graphs to the right. Data in bar graphs show individual biological replicate values and average ± sem from n=3 biologically independent samples/group.