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. Author manuscript; available in PMC: 2023 Apr 24.
Published in final edited form as: Nat Chem Biol. 2022 Feb 24;18(4):412–421. doi: 10.1038/s41589-022-00971-2

Extended Data Figure 14. IsoTOP-ABPP analysis of NJH-2-057.

Extended Data Figure 14.

CFBE41o-4.7 cells expressing ΔF508-CFTR were treated with vehicle DMSO or NJH-2-057 for 8 h. Resulting cell lysates were labeled with IA-alkyne (200 μM) for 1 h and taken through the isoTOP-ABPP procedure. Shown in red are the probe-modified peptides that showed isotopically light/heavy or control/NJH-2-57 ratios >4 with adjusted p-values <0.05. The data are from n=3 biologically independent samples/group. The full isoTOP-ABPP dataset can be found in Table S4.