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. 2022 Dec 1;3(1):97–113. doi: 10.1021/acsbiomedchemau.2c00061

Figure 4.

Figure 4

Antitumor effect in the postsurgical relapse 4T1-luc tumor model in mice. (a) Surgical and treatment procedures of 4T1-luc tumor relapse model. iv., intravenous. (b) In vivo IVIS images of 4T1-luc tumors after resection of the primary tumor. (c) The relative tumor volumes after treating with saline, DOX, DHA, DOX + DHA, and DOX/DHA-LNs for four times with equivalent doses of 5.00 mg kg–1 of DOX and 2.83 mg kg–1 of DHA. (d) Photographs of tumors collected from mice were treated as indicated after 12 days. (e) The variation profiles of body weights. (f) Survival curves of the treatment groups up to 40 days after administration (n = 10). P values were determined by one-way ANOVA with post hoc Tukey test and represented using *P < 0.05 and **P < 0.01.