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. 2023 Feb 15;3(2):158–173. doi: 10.1021/acsbiomedchemau.2c00067

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© 2023 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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(A) Quantification of percentage apoptotic cells of different treatments shows the significant rescue of cells from Aβ42-induced apoptosis by NT-02, NT-03, and NT-13 peptides. Effects of NT peptides on Aβ42 aggregation measured by the ThT fluorescence assay. (B) Peptides NT-02, (C) NT-03, and (D) NT-13 in Aβ42 aggregation. The control sample represents the Aβ42 peptide (5 μM) alone. (E–G) Effects of peptides NT-02, NT-03, and NT-13 on Aβ42 aggregation for 7 days. Aβ42 (5 μM) and peptide at a 10 μM concentration. Control sample represents the Aβ42 peptide (5 μM) alone. (H) Serum stability of NT peptides in human serum up to 24 h. Error bars represent mean ± standard deviation (SD), n = 3. Statistical data were analyzed by a one-way ANOVA test by the multiple comparison tests (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, vs Aβ42) using software GraphPad Prism (ISI, San Diego, CA).