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. 2023 Feb 15;3(2):158–173. doi: 10.1021/acsbiomedchemau.2c00067

Figure 5.

Figure 5

ITC experiment of NT peptides showing interaction with the Aβ42 peptide. (A) NT-02 peptide shows an affinity of 2.25 × 106 ± 1.023 × 105 M–1, (B) NT-03 peptide shows an affinity of (3.47 ± 1.23) × 106 M–1, and (C) NT-13 peptide shows an affinity of 1.42 × 105 ± 3.42 × 104 M–1. Molecular docking images of NT peptides with the Aβ42 peptide (PDB ID: 1Z0Q). (D) Docking studies of the NT-02 peptide with the Aβ42 peptide show H-bonding interaction with a −5.2 kcal/mol binding energy. (E) Docking studies of NT-03 with Aβ42 and showing H-bonding interactions with −5.3 kcal/mol binding energy. (F) Docking studies of NT-13 with Aβ42 and showing H-bonding interaction with a −4.5 kcal/mol binding energy.