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. 2023 Jan 13;34(5):755–771. doi: 10.1681/ASN.0000000000000063

Figure 2.

Figure 2

TIGIT expression increases in human kidney T cells after ischemic injury and in patients with AKI. (A) Flow dot plot and graphs showing percentage (left graph) of TIGIT+ CD4, CD8, and DN T cells in preclamp and postclamp human kidney. Corresponding bar graphs showing absolute numbers of TIGIT+ cells in the same preclamp and postclamp kidney tissue. Data were analyzed using the nonparametric Mann-Whitney test to compare preclamp and postclamp groups separately for CD4, CD8, and DN T cells. Graphs in Figure 2A represent median (IQR) values. (B) Reference UMAP of the NIH kidney precision medicine project (KPMP) scRNA-Seq data showing different kidney cell clusters identified for scRNA-Seq data set. (C and D) UMAPs showing TIGIT expression in T/NK cells cluster of healthy controls (n=20) and patients with AKI (n=12). Arrow showing position of T/NK cell cluster. *P≤0.05. KPMP, kidney precision medicine project; TIGIT, T-cell immunoreceptor with Ig and ITIM domains.