Figure 3.

Curcumin inhibits diabetes-induced myocardial pyroptosis. DM: diabetic rat; Cur: curcumin; the dose used in animal experiments was 200 mg/kg/day. ml385: inhibitors of the Nrf2 pathway, the dose used in the experiment was 20 mg/kg. (a) The expression of pyroptosis proteins in rat myocardial tissue was detected by western blotting. (b–d) Expression levels of IL-18, IL-1, NF-κB, TNF-α, BNP, and SOD in the serum of the rats in each group were determined using an enzyme-linked immunosorbent assay vs. the control group and curcumin-treated group. #^∗P < 0.001: injected with ml385 vs. noninjected with ml385 (in diabetic rats). Values are expressed as the mean ± standard deviation.