TABLE 2.
Radiologic features of SSNs with growth and stable under long‐term follow‐up
| Feature | Total SSNs (n = 361) | SSNs with growth (n = 188) | SSNs stable (n = 173) | p value |
|---|---|---|---|---|
| Initial nodule type | <0.001 | |||
| pGGN | 233 (64.5%) | 106 (56.3%) | 127 (73.4%) | |
| hGGN | 93 (25.8%) | 52 (27.7%) | 41 (23.7%) | |
| rPSN | 35 (9.7%) | 30 (16.0%) | 5 (2.9%) | |
| Lesion location | 0.148 | |||
| RUL | 122 (33.8%) | 70 (37.2%) | 52 (30.1%) | |
| RML | 20 (5.5%) | 8 (4.3%) | 12 (6.9%) | |
| RLL | 67 (18.62%) | 34 (18.1%) | 33 (19.1%) | |
| LUL | 109 (30.2%) | 60 (31.9%) | 49 (28.3%) | |
| LLL | 43 (11.9%) | 16 (8.5%) | 27 (15.6%) | |
| Initial diameter (mm) | 7.0 (5.6–9.0) | 8.0 (6.0–12.0) | 6.4 (5.4–7.6) | <0.001 |
| Initial diameter classification (mm) | <0.001 | |||
| 2.0–3.9 | 10 (2.8%) | 9 (4.8%) | 1 (0.6%) | |
| 4.0–5.9 | 92 (25.5%) | 29 (15.4%) | 63 (36.4%) | |
| 6.0–7.9 | 127 (35.2%) | 48 (25.5%) | 79 (45.7%) | |
| 8.0–9.9 | 58 (16.0%) | 34 (18.1%) | 24 (13.9%) | |
| ≥10.0 | 74 (20.5%) | 68 (36.2%) | 6 (3.5%) | |
| Initial diameter of solid component in LW (mm) | 2.3 (1.8–3.8) | 3.0 (2.0–4.5) | 2.0 (1.5–2.3) | <0.001 |
| Initial diameter of solid component in MW (mm) | 2.8 (1.4–3.5) | 2.4 (1.2–3.4) | 1.8 (1.7–3.6) | 0.766 |
| Initial mean CT value (HU) | −705.8 ± 85.8 | −703.5 ± 86.5 | −708.3 ± 85.2 | 0.601 |
| CTR classification in LW | 0.003 | |||
| 0 | 233 (64.5%) | 106 (56.4%) | 127 (73.4%) | |
| 0.01–0.25 | 53 (14.7%) | 32 (17.0%) | 21 (12.1%) | |
| 0.26–0.50 | 62 (17.2%) | 39 (20.7%) | 23 (13.3%) | |
| >0.5 | 13 (3.6%) | 11 (5.9%) | 2 (1.2%) | |
| CTR classification in MW | <0.001 | |||
| 0 | 326 (90.3%) | 158 (84.0%) | 168 (97.1%) | |
| 0.01–0.10 | 7 (1.9%) | 7 (3.7%) | 0 (0.0%) | |
| 0.11–0.20 | 15 (4.2%) | 12 (6.4%) | 3 (1.7%) | |
| 0.21–0.30 | 6 (1.7%) | 6 (3.2%) | 0 (0.0%) | |
| 0.31–0.40 | 2 (0.6%) | 2 (1.1%) | 0 (0.0%) | |
| 0.41–0.50 | 4 (1.1%) | 2 (1.1%) | 2 (1.2%) | |
| >0.5 | 1 (0.3%) | 1 (0.5%) | 0 (0.0%) | |
| Radiologic findings | ||||
| Lobulated sign | 31 (8.6%) | 20 (10.6%) | 11 (6.4%) | 0.147 |
| Vacuole sign | 54 (15.0%) | 40 (21.3%) | 14 (8.1%) | <0.001 |
| Vascular sign | 159 (44.0%) | 98 (52.1%) | 61 (35.3%) | 0.001 |
| Pleural adhesion | 87 (24.1%) | 38 (20.2%) | 49 (28.3%) | 0.072 |
| Pleural retraction | 2 (1.2%) | 13 (6.9%) | 15 (4.2%) | 0.006 |
| Follow‐up duration (months) | 70.2 (59.8–87.5) | 62.0 (46.3–86.8) | 73.8 (68.1–88.4) | <0.001 |
| Time to nodule enlargement (months) | NA | 35.0 (21.3–55.0) | NA | NA |
| Total number of CT scans per patient | 7.0 (4.0–9.0) | 5.0 (4.0–8.0) | 7.0 (6.0–10.0) | <0.001 |
Note: Values are expressed as a number (%) or the mean ± standard deviation or median (IQR). Initial diameter of the solid component was measured when hGGNs and rPSNs were detected on the initial chest CT.
Abbreviations: CT, computed tomography; CTR, maximum diameter of consolidation relative to the maximum tumor diameter; hGGN, heterogeneity ground‐glass nodule; IQR, interquartile range; LLL, left lower lobe; LUL, left upper lobe; LW, lung window; MW, mediastinum window; pGGN, pure ground‐glass nodule; RLL, right lower lobe; RML, right middle lobe; rPSN, real part‐solid nodule; RUL, right upper lobe; SSN, subsolid nodule.