Comparison 1. Fecal microbiota transplantation (FMT) versus control for the treatment of recurrent Clostridioides difficile infections (rCDI).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Resolution of rCDI: intention‐to‐treat analysis	6	320	Risk Ratio (M‐H, Random, 95% CI)	1.92 [1.36, 2.71]
1.2 Resolution of rCDI: sensitivity analysis: fixed‐effect model	6	320	Risk Ratio (M‐H, Fixed, 95% CI)	1.92 [1.58, 2.34]
1.3 Resolution of rCDI: sensitivity analysis: as‐available analysis	6	313	Risk Ratio (M‐H, Random, 95% CI)	1.89 [1.31, 2.73]
1.4 Resolution of rCDI: sensitivity analysis: excluding immunocompromised participants	5	256	Risk Ratio (M‐H, Random, 95% CI)	1.81 [1.23, 2.66]
1.5 Serious adverse events: intention‐to‐treat analysis	6	320	Risk Ratio (M‐H, Random, 95% CI)	0.73 [0.38, 1.41]
1.6 Serious adverse events: sensitivity analysis: fixed‐effect model	6	320	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.38, 1.09]
1.7 Serious adverse events: sensitivity analysis: as‐available analysis	6	314	Risk Ratio (M‐H, Random, 95% CI)	0.72 [0.37, 1.38]
1.8 Serious adverse events: sensitivity analysis: excluding immunocompromised participants	5	256	Risk Ratio (M‐H, Random, 95% CI)	0.72 [0.30, 1.74]
1.9 All‐cause mortality: intention‐to‐treat analysis	6	320	Risk Ratio (M‐H, Random, 95% CI)	0.57 [0.22, 1.45]
1.10 All‐cause mortality: sensitivity analysis: fixed‐effect model	6	320	Risk Ratio (M‐H, Fixed, 95% CI)	0.52 [0.22, 1.23]
1.11 All‐cause mortality: sensitivity analysis: as‐available analysis	6	314	Risk Ratio (M‐H, Random, 95% CI)	0.50 [0.17, 1.46]
1.12 All‐cause mortality: sensitivity analysis: excluding immunocompromised participants	5	256	Risk Ratio (M‐H, Random, 95% CI)	0.57 [0.22, 1.45]
1.13 Withdrawals	6	320	Risk Ratio (M‐H, Random, 95% CI)	0.75 [0.17, 3.28]