Table 4.
Incidence and severity of OA-related microscopic findings in mice—unscheduled sacrifices.
| Sex | OA | |||||||
|---|---|---|---|---|---|---|---|---|
| Malesa | Femalesb | |||||||
| Test article virus concentration (vg/kg) | Vehicle control | 1.5 × 1014 vg/kg | 2.4 × 1014 vg/kg | 3.0 × 1014 vg/kg | Vehicle control | 1.5 × 1014 vg/kg | 2.4 × 1014 vg/kg | 3.0 × 1014 vg/kg |
| Heart | ||||||||
| Number examined | 1 | 0 | 1 | 5 | 2 | 1 | 2 | 5 |
| Inflammation, mononuclear, ventricle | ||||||||
| Minimal | 0 | NE | 1 | 5 | 0 | 0 | 1 | 2 |
| Edema, ventricle | ||||||||
| Minimal | 0 | NE | 1 | 3 | 0 | 1 | 0 | 0 |
| Fibrosis, myocardium, ventricle | ||||||||
| Minimal | 0 | NE | 1 | 5 | 0 | 0 | 2 | 4 |
| Thrombus, atrium | ||||||||
| Minimal | 0 | NE | 0 | 0 | 0 | 0 | 1 | 2 |
| Slight | 0 | NE | 0 | 1 | 0 | 0 | 1 | 1 |
| Moderate | 0 | NE | 0 | 2 | 0 | 0 | 0 | 1 |
| Dilation, atrium | ||||||||
| Slight | 0 | NE | 0 | 2 | 0 | 0 | 1 | 2 |
| Moderate | 0 | NE | 0 | 1 | 0 | 0 | 0 | 0 |
| Marked | 0 | NE | 0 | 1 | 0 | 0 | 0 | 0 |
| Fibroplasia, atrium | ||||||||
| Minimal | 0 | NE | 0 | 1 | 0 | 0 | 1 | 2 |
| Slight | 0 | NE | 0 | 3 | 0 | 0 | 1 | 2 |
| Degeneration/necrosis, myocardium, atrium | ||||||||
| Minimal | 0 | NE | 0 | 3 | 0 | 0 | 0 | 2 |
| Slight | 0 | NE | 0 | 1 | 0 | 0 | 2 | 3 |
| Inflammation, mononuclear, atrium | ||||||||
| Minimal | 0 | NE | 0 | 4 | 0 | 0 | 1 | 4 |
NE not examined.
aOne male (Animal M0218-2) administered 2.4 × 1014 vg/kg was not examined microscopically due to extensive autolysis.
bOne control female (Animal M0020-6) was not examined microscopically due to extensive autolysis.