Table 5.
Incidence and severity of OA-related microscopic heart findings in mice—week 3 (PND 21) terminal sacrifice.
| Sex | OA | |||||||
|---|---|---|---|---|---|---|---|---|
| Males | Females | |||||||
| Test article virus concentration (vg/kg) | Vehicle control | 1.5 × 1014 vg/kg | 2.4 × 1014 vg/kg | 3.0 × 1014 vg/kg | Vehicle control | 1.5 × 1014 vg/kg | 2.4 × 1014 vg/kg | 3.0 × 1014 vg/kg |
| Heart | ||||||||
| Number examined | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Inflammation, mononuclear, ventricle | ||||||||
| Minimal | 0 | 4 | 5 | 3 | 0 | 3 | 5 | 3 |
| Slight | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 |
| Edema, ventricle | ||||||||
| Minimal | 0 | 0 | 4 | 2 | 0 | 1 | 3 | 3 |
| Fibrosis, myocardium, ventricle | ||||||||
| Minimal | 0 | 0 | 3 | 3 | 0 | 3 | 5 | 3 |
| Slight | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| Inflammation, mononuclear, atrium | ||||||||
| Minimal | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 |