TABLE 1.
Benchmark scenario and reporting outcomes for Scenarios A (starting in MCI) and B (starting in mild dementia)
| Aspect | Specification |
|---|---|
| Population | Scenario A: persons with MCI due to AD (analyst to detail diagnostic criteria used, for example, on use of biomarkers or clinical criteria). Scenario B: persons with AD-type mild dementia (analyst to detail diagnostic criteria). |
| Starting age | 70 years. |
| Setting | Clinical (typically memory clinic), with patients already identified for treatment (no procedures or costs for diagnostics to be included). |
| Control strategy | Usual care (e.g., including cholinesterase inhibitor treatment). |
| Intervention strategy | Disease-modifying intervention, resulting in 30% reduction in progression (e.g., rate ratio of 0.70 for conversion from MCI to dementia [Scenario A] or mild to moderate dementia [Scenario B] or other comparable effect as defined by analyst). Analyst determines criteria of mild and moderate dementia, whether treatment effects extend after discontinuation of treatment, and whether treatment effects mortality. |
| Stopping rule | Scenario A: intervention in MCI state and treated until conversion to dementia. Scenario B: intervention in dementia state and treated until moderate dementia. Both in Scenario A and B: treatment for a maximum of 5 years. |
| Treatment discontinuation | 10% per year. |
| Time horizon | 10 and 20 years. |
| Discount rate | Costs and QALYs both 3.5%. |
| Half-cycle correction | If applicable (i.e., if Markov-type cycle duration was used). |
| Outcomes | Mean person-years: alive, in MCI, mild dementia, moderate dementia, severe dementia, on intervention, full-time care, or living in institutionalized setting. Proportion/occupancy of patients in states MCI, mild, moderate, severe, and death by year since baseline. Mean discounted costs (disaggregated to intervention, direct medical, direct nonmedical costs), mean discounted QALY (patient only), incremental cost-effectiveness ratio. |
Abbreviations: AD, Alzheimer’s Disease; MCI, Mild Cognitive Impairment; QALY, quality-adjusted life year.