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. 2023 Apr 24;13(4):e1234. doi: 10.1002/ctm2.1234

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© 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Inflammatory communication in the myometrium of the term in non‐labour (TNL) and term in labour (TIL) groups (A) The total interactions number in the TNL and TIL groups using scRNA‐seq. (B) A differential number of interactions (all ligand‐receptor in CellChatDB database) of major cell populations in the myometrium of TNL and TIL groups. The degree of thickness indicates the interaction number between the sender and the receiver. The red line indicates an increase in the TIL group, and the blue line indicates a decrease in the TIL group. (C) The number of inflammatory interactions (inflammatory ligand‐receptor in CellChatDB database) of cell subpopulations of TNL and TIL groups. The degree of thickness indicates the interaction number between the sender and the receiver. (D) Heatmap of the aggregated cell‐cell communication of representative inflammatory interactions among cell subpopulations in the myometrium of TNL and TIL groups. The colour represents the calculated communication probability. (E) Immunofluorescence indicates the location of three major cell populations in the myometrium of TNL and TIL groups, SMC (ACTA), macrophage (CD68), and endothelial cells (VWF). (F) The number of interactions (all ligand‐receptor in the CellChatDB database) among the three major cell populations in populations myometrium of TNL and TIL groups. (G) The abstract of potential cross‐talks focusing on immune response and SMC contraction in myometrium during labour.