Table 3.
Risk of Incident Dementia According to Individual-Level Socioeconomic Deprivation
| Individual-level socioeconomic deprivationa | Model 1b | Model 1b | Model 1b | Model 2c | Model 2c | Model 2c | Model 3d | Model 3d | Model 3d |
|---|---|---|---|---|---|---|---|---|---|
| Low (n=39,274) | Intermediate (n=117,821) | High (n=39,273) | Low (n=39,274) | Intermediate (n=117,821) | High (n=39,273) | Low (n=39,274) | Intermediate (n=117,821) | High (n=39,273) | |
| Number of dementia cases/person-yearsa | 174/309,221 | 1,042/929,551 | 553/306,541 | 174/309,221 | 1,042/929,551 | 553/306,541 | 174/309,221 | 1,042/929,551 | 553/306,541 |
| HR (95% CI) | 1 (ref) | 1.63 (1.38, 1.93) | 2.57 (2.14, 3.08) | 1 (ref) | 1.63 (1.38, 1.93) | 2.57 (2.14, 3.09) | 1 (ref) | 1.62 (1.37, 1.92) | 2.38 (1.98, 2.87) |
| p-value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |||
| p-value of trende | <0.001 | <0.001 | <0.001 |
Note: Boldface indicates statistical significance (p<0.001).
HR, hazard ratio; PC, principal component.
a
Reported results are based on the first imputed data set.
b
All Cox proportional-hazards regressions were adjusted for the 20 first PCs, third-degree relatedness, age, sex, education, and marital status.
c
Model 2 included adjustments of Model 1, polygenic risk, and the number of alleles used to compute the polygenic risk score.
d
Model 3 included adjustments of Model 2 and area-level socioeconomic deprivation.
e
p-value for trend was assessed using the continuous score of individual-level socioeconomic deprivation.