Table 1.
Organ function parameters for the heart, the lungs, and the kidneys before (pre) and after 2 hrs of hemorrhagic shock and acute subdural hematoma (post) as well as 24 hrs and 48 hrs after resuscitation.
| Parameter | Group | pre | post | 24 hrs | 48 hrs |
|---|---|---|---|---|---|
| Body Temperature (°C) | C | 35.8 (35.0; 35.8) | 35.3 (35.0; 36.3) | 37.1 (36.9; 38.1) | 38.0 (37.5; 38.1) |
| H | 35.0 (34.8; 36.0) | 34.8 (34.2; 36.1) | 37.9 (37.2; 38.3) | 37.8 (37.6; 38.2) | |
| Heart Rate (beats × min−1) | C | 64 (56, 71) | 130 (123, 134) | 59 (52; 65) | 96 (54; 150) |
| H | 63 (49; 71) | 127 (107; 133) | 55 (53; 60) | 73 (64; 110) | |
| Stroke Volume (ml) | C | 101 (90; 117) | 34 (29; 48) | 100 (76; 114) | 95 (70; 99) |
| H | 114 (102; 133) | 34 (32; 42) | 95 (79; 107) | 88 (57; 103) | |
| Stroke Volume Variation (%) | C | 8 (6; 11) | 12 (10; 14) | 12 (10; 17) | 5 (4; 6) |
| H | 10 (5; 12) | 12 (10; 13) | 8 (5; 15) | 7 (5; 14) | |
| Cardiac Output (l × min−1) | C | 6.4 (6.1; 7.9) | 4.5 (3.9; 6.0) | 6.2 (5.1; 8.1) | 9.5 (5.7; 10.3) |
| H | 6.4 (4.8; 7.0) | 4.1 (2.7; 4.5) | 5.3 (4.6; 6.3) | 6.4 (4.4; 9.6) | |
| MAP (mmHg) | C | 98 (90; 105) | 63 (61; 72) | 119 (117; 144) | 110 (101; 155) |
| H | 99 (91; 112) | 61 (57; 67) | 131 (125; 136) | 115 (109; 124) | |
| Central Venous Pressurea (mmHg) | C | 8 (7; 10) | 4 (2; 5) | 13 (10; 13) | 12 (12; 12) |
| H | 8 (6; 9) | 5 (3; 6) | 12 (11; 14) | 11 (9; 14) | |
| Urine Output (ml−1 × h−1 × kg−1) | C | 10.7 (5.8; 12.6) | not measured | 5.7 (1.3; 6.4) | 9.4 (1.6; 9.8) |
| H | 10.9 (8.3; 11.5) | not measured | 4.7 (3.8; 6.2) | 5.2 (3.0; 6.0) | |
| Positive end-expiratory pressure (cmH2O) | C | 0 (0; 0) | 0 (0; 0) | 10 (10; 10) | 10 (10; 10) |
| H | 0 (0; 0) | 0 (0; 0) | 10 (10; 10) | 10 (10; 10) | |
| Respiratory Minute Volume (l × min−1) | C | 4.5 (4.2; 5.5) | 4.5 (3.9; 5.2) | 5.9 (5.7; 29.4) | 6.0 (5.3; 6.8) |
| H | 4.8 (4.5; 5.1) | 4.8 (4.5; 5.3) | 6.7 (6.4; 7.3) | 7.0 (6.8; 8.8)b | |
| Arterial PO2 (mmHg) | C | 71 (65; 87) | 88 (84; 104) | 85 (80; 99) | 90 (79; 107) |
| H | 76 (65; 92) | 95 (77; 104) | 233 (216; 243)** | 89 (87; 95) | |
| PaO2/FIO2 ratio (mmHg) | C | 338 (311; 413) | 417 (402; 495) | 397 (371; 415) | 391 (317; 428) |
| H | 361 (311; 437) | 453 (365; 495) | 491 (479; 540)** | 387 (358; 409) | |
| Arterial PCO2 (mmHg) | C | 38.1 (37.1; 42.5) | 38.7 (33.8; 45.7) | 40.7 (37.9; 41.2) | 38.8 (38.4; 44.1) |
| H | 36.0 (35.0; 41.2) | 41.6 (36.7; 43.5) | 39.0 (34.1; 41.5) | 38.4 (35.7; 43.8) | |
| Oxygen Consumption (ml × min−1) | C | 185 (176; 218) | 166 (153; 185) | 215 (190; 265) | 235 (207; 285) |
| H | 179 (160; 194) | 144 (130; 189) | 194 (135; 237) | 233 (209; 246) | |
| Carbon Dioxide Generation (ml × min−1) | C | 136 (120; 163) | 136 (120; 155) | 175 (130; 203) | 202 (187; 243) |
| H | 138 (121; 146) | 119 (105; 154) | 190 (167; 208) | 211 (183; 236) | |
| Troponin (ng × ml−1) | C | 0.03 (0.02; 0.19) | 0.07 (0.02; 0.16) | 1.30 (0.81; 4.04) | 0.60 (0.16; 0.78) |
| H | 0.02 (0.02; 0.02) | 0.02 (0.02; 0.02) | 0.41 (0.04; 1.71) | 0.06 (0.01; 1.90) | |
| NGAL (ng × ml−1) | C | 303 (259; 356) | 379 (334; 633) | 726 (507; 1 865) | 748 (577; 2 079) |
| H | 311 (270; 383) | 438 (392; 570) | 523 (507; 1 163) | 825 (783; 2 167) | |
| Superoxide Anion (µm × l−1) | C | 5.7 (5.6; 6.1) | 5.6 (4.7; 5.9) | 6.5 (5.4; 6.8) | 5.2 (4.5; 6.0) |
| H | 6.3 (5.2; 6.4) | 5.2 (4.9; 5.4) | 6.4 (5.2; 7.0) | 6.2 (5.3; 6.6) |
n = 7/7 before shock, 7/7 after shock, 5/6 at 24 hrs, and 3/5 at 48 hrs per group for normoxemia (blue, control group, C) and targeted hyperoxemia (red, H), respectively. For the central venous pressurea, see method section for further details. Values are reported as median and interquartile range. p-values are reported when below 0.1, b denotes p = 0.07, ** = p < 0.01, Mann-Whitney U test.