Table 4.

Comparison of symptom burden at baseline and week 4 between the groups.

Symptoms	TOLF-HF group (n = 29), median (IQR)	Control group (n = 31), median (IQR)	Z	P value*
Shortness of breath
Baseline	2.50 (1.50–3.00)	2.00 (1.50–3.00)	0.079	0.937
Week 4	0.00 (0.00–1.00)	1.00 (0.00–2.00)	−2.439	0.015
Difficulty breathing when lying flat
Baseline	2.00 (1.00–3.00)	2.50 (1.00–3.00)	−0.821	0.412
Week 4	0.00 (0.00–0.00)	0.00 (0.00–1.00)	−1.042	0.297
Cough
Baseline	2.00 (1.50–3.00)	2.00 (1.00–3.00)	−0.191	0.848
Week 4	0.00 (0.00–1.00)	1.25 (0.00–2.00)	−2.052	0.040
Lack of energy
Baseline	2.00 (1.00–3.00)	2.00 (0.00–2.50)	−0.071	0.943
Week 4	0.00 (0.00–1.00)	1.00 (0.00–1.50)	−1.492	0.136
Swelling of arms or legs
Baseline	2.75 (1.25–4.00)	3.00 (0.50–3.75)	−1.852	0.064
Week 4	0.00 (0.00–1.00)	1.00 (0.00–1.50)	−2.305	0.021
Waking up breathless at night
Baseline	1.50 (0.00–2.38)	1.50 (0.00–2.50)	−0.983	0.326
Week 4	0.00 (0.00–1.38)	0.50 (0.00–1.00)	−1.209	0.227

IQR, inter-quartile range.

^*P values were derived from the Mann–Whitney U-test.