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. 2023 Apr 11;14:1146468. doi: 10.3389/fphar.2023.1146468

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Copyright © 2023 Zhu, Deng, Wang, Rahat, Sun and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TEX and TIME characteristics of each CuRGcluster. (A) Survival analyses for the three CuRGclusters based on 1012 patients from the training cohort (GSE30219, GSE31210, GSE37745, GSE50081, TCGA-LUAD). (B) Immune score analyses using the ESTIMATE algorithm in three CuRGclusters. (C) The abundance of each tumor microenvironment infiltrating cell in CuRGcluster A-C. (D–H) GSVA enrichment analysis between CuRGcluster A-C with TEX-related signatures (D), signal pathways (E), immune checkpoint genes (F), transcription factors (G), or inflammatory factors (H). The line in the box represents the median value, and the asterisk represents the p-value. *p < 0.05; **p < 0.01; ***p < 0.001.