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. 2023 Apr 11;14:1146468. doi: 10.3389/fphar.2023.1146468

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Copyright © 2023 Zhu, Deng, Wang, Rahat, Sun and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival analyses for subgroups of patients stratified by CuRGscores and immune checkpoint genes in the training cohort. (A–D) Survival analysis to examine the OS of patients with LUAD in four TEX subtypes, including GZMK+ (A), OXPHOS- (B), TCF7+ (C), and terminal TEX phenotypes (D). (E–H) Prognosis analysis for patients with LUAD patients stratified into four groups by CuRGscore and four TEX subtypes, including GZMK+ (E), OXPHOS- (F), TCF7+ (G), and terminal TEX phenotypes (H). (I–P) Kaplan-Meier curves analyzed the overall survival of patients with LUAD, stratified into four groups by CuRGscores and checkpoint genes, such as TIGIT (I), CTLA4 (J), IDO1 (K), LAG3 (L), PDCD1 (M), HAVCR2 (N), SIGLEC7 (O) and CD274 (P).